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IVF BIG DATA

Embryo morphology in IVF cycles - exploratory analysis

Exploratory views over the full dataset (4,596 FET records): morphology, maternal age, biopsy day (day 5 vs day 6), and clinical pregnancy rates. These panels are not filtered by the ongoing PR calculator; they always reflect the full cohort.

Embryo morphology — frequency

Number of FET cycles per morphology Gardner grade (most frequent grades by count).
5AA
863
3AA
511
5AB
511
3AB
426
5BB
353
3BB
280
4AA
232
4AB
231
6BB
163
6AA
157
5BA
107
4BB
103
6AB
83
2AB
73
2AA
71
3BB-
53
6BA
49
2BB
42
3BA
33
5BB-
26
6B-B
21
3B-B-
21
5B-B
20
4BB-
18
5B-B-
18
4BA
17
3B-B
16
2BB-
15
6BB-
15
4B-B-
10
6B-B-
10
5AB-
10
2B-B-
8
2BA
6
3AB-
6
4AB-
3
2BC
2
2B-B
2
3AA
1
4B-B
1
5BB
1
3BB
1
5AB
1
2B-C
1
5BA
1

Embryo age — frequency

Number of FET cycles per maternal age in the dataset.
20
2
21
5
22
14
23
13
24
19
25
41
26
35
27
32
28
63
29
85
30
130
31
184
32
256
33
292
34
345
35
401
36
421
37
488
38
462
39
422
40
336
41
237
42
165
43
92
44
33
45
12
46
8
47
1
49
1
51
1

Biopsy day — frequency

Number of FET cycles by biopsy day (day 5 vs day 6 in this cohort).
Day 5 biopsy
2,822
Day 6 biopsy
1,757
Day 7 biopsy
17

Biopsy day vs Clinical PR

Clinical pregnancy rate (IUP / FET × 100%) by biopsy day. Bar length = clinical PR; n = FET cycles in each group.
0%25%50%75%100%Day 5 — 78.84% clinical PR (2225 IUP / 2822 FET)Day 578.84%n=2822Day 6 — 62.32% clinical PR (1095 IUP / 1757 FET)Day 662.32%n=1757Day 7 — 52.94% clinical PR (9 IUP / 17 FET)Day 752.94%n=17

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Morphology and maternal age

Heatmap of FET counts for the most frequent morphologies (rows) × maternal ages (columns). Darker blue = more cycles in that cell.
Morphology202122232425262728293031323334353637383940414243444546474951
5AA
1
1
3
3
11
8
9
15
12
32
38
48
65
77
83
86
92
80
69
51
38
21
9
4
5
1
1
3AA
1
1
2
3
3
5
5
16
26
39
44
38
48
53
56
62
34
42
13
9
6
4
1
5AB
1
2
2
1
5
4
6
9
12
10
17
29
31
30
45
41
54
61
51
38
28
23
7
2
2
3AB
1
1
1
5
6
1
6
10
11
18
20
33
28
36
41
54
36
30
36
20
19
7
4
1
1
5BB
3
1
4
3
1
2
3
7
5
14
19
13
23
31
28
40
28
50
30
18
15
10
2
2
1
3BB
1
1
1
1
3
2
3
3
5
8
8
13
13
19
23
19
22
24
23
23
24
17
12
7
3
1
1
4AA
1
1
4
1
3
2
8
8
16
16
23
25
17
24
20
21
18
11
7
4
2
4AB
1
2
1
4
4
8
14
11
14
23
14
31
21
29
18
12
10
7
4
1
1
1
6BB
1
1
3
2
1
3
1
4
9
6
7
6
5
12
15
14
20
18
9
14
7
5
6AA
1
3
1
1
2
3
3
5
9
8
10
16
15
16
14
17
12
9
2
5
4
1
5BA
2
2
2
2
2
6
7
9
15
8
10
12
10
5
9
4
1
1
4BB
1
1
1
4
1
4
4
4
9
11
8
11
12
6
7
8
5
5
1
6AB
1
3
1
2
8
6
7
5
12
8
11
8
5
4
1
1
2AB
1
1
1
2
6
4
8
6
10
7
8
8
3
5
1
2
2AA
1
1
1
4
8
5
10
7
7
11
4
5
4
2
1
3BB-
3
1
1
1
2
4
3
2
2
6
5
6
5
4
2
4
1
1

Morphology and biopsy day

Heatmap of FET counts for the most frequent morphologies (rows) × biopsy day (columns: 5 = day 5 biopsy, 6 = day 6 biopsy). Darker blue = more cycles in that cell.
MorphologyDay 5Day 6Day 7
5AA
551
311
1
3AA
471
40
5AB
312
197
2
3AB
355
70
1
5BB
95
257
1
3BB
197
81
2
4AA
199
33
4AB
189
42
6BB
14
148
1
6AA
49
108
5BA
39
67
1
4BB
56
46
1
6AB
26
56
1
2AB
63
10
2AA
67
4
3BB-
24
28
1

Quality of the embryos vs clinical PR

Gardner grades (expansion 1–6 + ICM + TE). Each row lists the category and a short definition below it. Bar length = clinical PR (IUP / FET × 100%). The table below splits the same quality groups by biopsy day (day 5 vs day 6).
0%25%50%75%100%Good (ICM/TE pairs AA, AB, or BA) — 76.38% clinical PR (2577 IUP / 3374 FET)GoodICM/TE pairs AA, AB, or BA76.38%n=3374Fair (ICM/TE pair BB) — 65.75% clinical PR (620 IUP / 943 FET)FairICM/TE pair BB65.75%n=943Borderline fair (Any B− on ICM or TE) — 47.46% clinical PR (131 IUP / 276 FET)Borderline fairAny B− on ICM or TE47.46%n=276Poor (Any C on ICM or TE) — 33.33% clinical PR (1 IUP / 3 FET)PoorAny C on ICM or TE33.33%n=3

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Same quality groups, stratified by biopsy day

Clinical PR in each cell (IUP / FET × 100%). Same PR bands as the chart above, with saturated fills: under 40% pink, 40–56% blue, 56% and above green. Empty cells had no FETs in that quality × biopsy-day combination.

QualityDay 5 biopsyDay 6 biopsyDay 7 biopsy
Good
ICM/TE pairs AA, AB, or BA
79.62%n=2,370
68.74%n=998
66.67%n=6
Fair
ICM/TE pair BB
76.1%n=385
58.59%n=553
60%n=5
Borderline fair
Any B− on ICM or TE
67.16%n=67
41.38%n=203
33.33%n=6
Poor
Any C on ICM or TE
—
33.33%n=3
—

Expansion grade vs Clinical PR

Gardner expansion grade (1–6) from the embryo grade. Bar length = clinical PR (IUP / FET × 100%).
0%25%50%75%100%Grade 1 — 0.00% clinical PR (0 IUP / 1 FET)Grade 10.00%n=1Grade 2 — 75.45% clinical PR (166 IUP / 220 FET)Grade 275.45%n=220Grade 3 — 74.94% clinical PR (1011 IUP / 1349 FET)Grade 374.94%n=1349Grade 4 — 76.10% clinical PR (468 IUP / 615 FET)Grade 476.10%n=615Grade 5 — 71.50% clinical PR (1367 IUP / 1912 FET)Grade 571.50%n=1912Grade 6 — 63.53% clinical PR (317 IUP / 499 FET)Grade 663.53%n=499

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Embryo morphology vs Clinical PR

Clinical pregnancy rate (IUP / FET × 100%) per morphology for the most frequent grades. Same layout as Clinical PR by morphology (0–100% scale, tier colors, n=).
0%25%50%75%100%5AA — 74.16% clinical PR (640 IUP / 863 FET)5AA74.16%n=8633AA — 81.02% clinical PR (414 IUP / 511 FET)3AA81.02%n=5115AB — 76.32% clinical PR (390 IUP / 511 FET)5AB76.32%n=5113AB — 75.82% clinical PR (323 IUP / 426 FET)3AB75.82%n=4265BB — 64.02% clinical PR (226 IUP / 353 FET)5BB64.02%n=3533BB — 71.43% clinical PR (200 IUP / 280 FET)3BB71.43%n=2804AA — 78.02% clinical PR (181 IUP / 232 FET)4AA78.02%n=2324AB — 81.82% clinical PR (189 IUP / 231 FET)4AB81.82%n=2316BB — 59.51% clinical PR (97 IUP / 163 FET)6BB59.51%n=1636AA — 74.52% clinical PR (117 IUP / 157 FET)6AA74.52%n=1575BA — 70.09% clinical PR (75 IUP / 107 FET)5BA70.09%n=1074BB — 66.02% clinical PR (68 IUP / 103 FET)4BB66.02%n=1036AB — 66.27% clinical PR (55 IUP / 83 FET)6AB66.27%n=832AB — 84.93% clinical PR (62 IUP / 73 FET)2AB84.93%n=732AA — 84.51% clinical PR (60 IUP / 71 FET)2AA84.51%n=713BB- — 62.26% clinical PR (33 IUP / 53 FET)3BB-62.26%n=536BA — 59.18% clinical PR (29 IUP / 49 FET)6BA59.18%n=492BB — 64.29% clinical PR (27 IUP / 42 FET)2BB64.29%n=423BA — 72.73% clinical PR (24 IUP / 33 FET)3BA72.73%n=335BB- — 34.62% clinical PR (9 IUP / 26 FET)5BB-34.62%n=266B-B — 52.38% clinical PR (11 IUP / 21 FET)6B-B52.38%n=213B-B- — 28.57% clinical PR (6 IUP / 21 FET)3B-B-28.57%n=215B-B — 70.00% clinical PR (14 IUP / 20 FET)5B-B70.00%n=204BB- — 50.00% clinical PR (9 IUP / 18 FET)4BB-50.00%n=185B-B- — 33.33% clinical PR (6 IUP / 18 FET)5B-B-33.33%n=184BA — 70.59% clinical PR (12 IUP / 17 FET)4BA70.59%n=173B-B — 37.50% clinical PR (6 IUP / 16 FET)3B-B37.50%n=162BB- — 60.00% clinical PR (9 IUP / 15 FET)2BB-60.00%n=156BB- — 33.33% clinical PR (5 IUP / 15 FET)6BB-33.33%n=154B-B- — 60.00% clinical PR (6 IUP / 10 FET)4B-B-60.00%n=106B-B- — 30.00% clinical PR (3 IUP / 10 FET)6B-B-30.00%n=105AB- — 50.00% clinical PR (5 IUP / 10 FET)5AB-50.00%n=102B-B- — 25.00% clinical PR (2 IUP / 8 FET)2B-B-25.00%n=82BA — 66.67% clinical PR (4 IUP / 6 FET)2BA66.67%n=63AB- — 33.33% clinical PR (2 IUP / 6 FET)3AB-33.33%n=64AB- — 66.67% clinical PR (2 IUP / 3 FET)4AB-66.67%n=32BC — 50.00% clinical PR (1 IUP / 2 FET)2BC50.00%n=22B-B — 0.00% clinical PR (0 IUP / 2 FET)2B-B0.00%n=23aa — 100.00% clinical PR (1 IUP / 1 FET)3aa100.00%n=14B-B — 100.00% clinical PR (1 IUP / 1 FET)4B-B100.00%n=1

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.

Age vs Clinical PR

Clinical pregnancy rate by maternal age with a sample size for each age group.
0%25%50%75%100%20 — 100.00% clinical PR (2 IUP / 2 FET)20100.00%n=221 — 80.00% clinical PR (4 IUP / 5 FET)2180.00%n=522 — 57.14% clinical PR (8 IUP / 14 FET)2257.14%n=1423 — 46.15% clinical PR (6 IUP / 13 FET)2346.15%n=1324 — 52.63% clinical PR (10 IUP / 19 FET)2452.63%n=1925 — 75.61% clinical PR (31 IUP / 41 FET)2575.61%n=4126 — 62.86% clinical PR (22 IUP / 35 FET)2662.86%n=3527 — 78.13% clinical PR (25 IUP / 32 FET)2778.13%n=3228 — 77.78% clinical PR (49 IUP / 63 FET)2877.78%n=6329 — 63.53% clinical PR (54 IUP / 85 FET)2963.53%n=8530 — 67.69% clinical PR (88 IUP / 130 FET)3067.69%n=13031 — 76.63% clinical PR (141 IUP / 184 FET)3176.63%n=18432 — 75.39% clinical PR (193 IUP / 256 FET)3275.39%n=25633 — 72.95% clinical PR (213 IUP / 292 FET)3372.95%n=29234 — 77.10% clinical PR (266 IUP / 345 FET)3477.10%n=34535 — 73.32% clinical PR (294 IUP / 401 FET)3573.32%n=40136 — 75.77% clinical PR (319 IUP / 421 FET)3675.77%n=42137 — 69.47% clinical PR (339 IUP / 488 FET)3769.47%n=48838 — 74.03% clinical PR (342 IUP / 462 FET)3874.03%n=46239 — 72.75% clinical PR (307 IUP / 422 FET)3972.75%n=42240 — 71.43% clinical PR (240 IUP / 336 FET)4071.43%n=33641 — 68.35% clinical PR (162 IUP / 237 FET)4168.35%n=23742 — 65.45% clinical PR (108 IUP / 165 FET)4265.45%n=16543 — 71.74% clinical PR (66 IUP / 92 FET)4371.74%n=9244 — 66.67% clinical PR (22 IUP / 33 FET)4466.67%n=3345 — 75.00% clinical PR (9 IUP / 12 FET)4575.00%n=1246 — 87.50% clinical PR (7 IUP / 8 FET)4687.50%n=847 — 100.00% clinical PR (1 IUP / 1 FET)47100.00%n=149 — 100.00% clinical PR (1 IUP / 1 FET)49100.00%n=151 — 0.00% clinical PR (0 IUP / 1 FET)510.00%n=1

Bar color: pink if clinical PR <40%, blue for 40–55%, green for ≥56%.